BCL2L11 — BCL2 like 11
BCL2L11 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BCL2L11's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B-cell signaling regulators B cell maturation | ACAP2, CDK13, EHMT1, FNBP1, ITSN2, JAK1, KMT2A, ST6GAL1 +3 more | View in SCUBA |
| CD4⁺ T cells | TCR Activation Signaling TCR/AP1/NFKb pathway | AKNA, ATP6V1A, KIF20B, LAX1, NAA50, NEDD9, NPC1, PRKAR1A +6 more | View in SCUBA |
| Gamma-delta T cells | AHR/NF-κB Survival Immune regulation | ABCC1, AHR, ANKRD37, AREG, BAIAP2, BEND4, BIRC3, CBL +24 more | |
| Natural Killer cells | NK Cytotoxic Signaling Cytotoxicity | CBLB, CRYBG1, DAZAP2, FYN, GPATCH8, HNRNPUL1, MAPK1, RAPGEF1 +3 more | View in SCUBA |
About the gene
| Synonyms | BIM, BimEL, BimL, BimS, BOD |
|---|---|
| Chromosome | 2: 111119378-111168445 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transporters |
| Biological process | Apoptosis |
Function
Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase- mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.