FNBP1 — Formin binding protein 1
FNBP1 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FNBP1's module in each cell type
About the gene
| Synonyms | FBP17, KIAA0554 |
|---|---|
| Chromosome | 9: 129887187-130043189 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Plasma proteins, Predicted intracellular proteins |
| Biological process | Endocytosis |
Function
May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.