ELK4 — ETS transcription factor ELK4
ELK4 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ELK4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TGF-beta response Intercellular communication | CLU, COA1, GLUL, GPR18, HDGFL3, ORAI2, RAB27B, RASSF2 +3 more | View in SCUBA |
| Endothelial | NF-κB Stress Signaling Inflammation | AKR1C3, EPS15, METRNL, MYCBP2, NFAT5, PALM, PELI2, PGM5 +4 more | View in SCUBA |
| Macrophages | RNA Splicing Processing Housekeeping | ARMCX3, CIRBP, GATAD1, H3-3B, HNRNPA2B1, HNRNPA3, HNRNPL, HP1BP3 +13 more | View in SCUBA |
About the gene
| Synonyms | SAP1 |
|---|---|
| Chromosome | 1: 205597556-205632011 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.