RNA Splicing Processing
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 22 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 22 genes have a known function matching the annotation |
Why this annotation
Hub genes include TIA1 (RNA-binding protein, stress granule assembly, splicing), SRSF3 (serine/arginine-rich splicing factor), HP1BP3 (heterochromatin protein 1 binding protein, chromatin), RBM14 (RNA-binding, splicing coactivator), HNRNPA2B1 (heterogeneous nuclear ribonucleoprotein, splicing/mRNA transport), SRSF2 (splicing factor), HNRNPA3 (splicing), HNRNPL (splicing), SUGP2 (splicing factor), CIRBP (cold-inducible RNA-binding protein, stress response). TIA1 is also a stress granule marker. UBE2W and UBE2G2 are ubiquitin-conjugating enzymes. H3-3B is histone H3.3. The dominant theme is RNA splicing/processing with a stress granule component (TIA1, CIRBP). This module neighbors M88 (splicing) and M67 (splicing), reinforcing the RNA processing theme. The stress granule angle (TIA1, CIRBP) adds a stress-response flavor but splicing is the dominant program.
Genes
ARMCX3, CIRBP, ELK4, GATAD1, H3-3B, HNRNPA2B1, HNRNPA3, HNRNPL, HP1BP3, HPS4, IREB2, PCSK7, RBM14, SRSF2, SRSF3, STX16, SUGP2, TCP1, TIA1, UBE2G2, UBE2W, ZFAND5
Most correlated modules
- General Cellular Maintenance · correlation 0.98
- Pre-mRNA Splicing · correlation 0.97
- mRNA Splicing Processing · correlation 0.95
- Chromatin Transcriptional Regulation · correlation 0.95
- Splicing Factor Regulation · correlation 0.94
- Autophagy Vesicular Trafficking · correlation 0.94
- Ubiquitin-ERAD Proteostasis · correlation 0.94
- Macrophage Endocytic Signaling · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.