FAM89B — Family with sequence similarity 89 member B
FAM89B belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FAM89B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Oxidative Phosphorylation Mitochondrial & OxPhos | AP2S1, ATP5F1C, ATP5PF, COPS9, COX6B1, EID1, FDPS, FIS1 +19 more | View in SCUBA |
| Goblet cells | Progenitor Identity Program Epithelial development | APEX1, MAP4K4, MEX3A, NOTCH1, NREP, RNF186, SOX4, TEAD2 +3 more | View in SCUBA |
| Macrophages | Mitochondrial OXPHOS Mitochondrial & OxPhos | ATP5IF1, ATP5MC2, ECH1, GMFG, GSTP1, HIGD2A, LAMTOR4, NDUFA12 +9 more | View in SCUBA |
About the gene
| Synonyms | LRAP25, MTVR1 |
|---|---|
| Chromosome | 11: 65572349-65574198 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.