LAMTOR4 — Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
LAMTOR4 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LAMTOR4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | NKG2D Cytotoxic Activation cytotoxicity | CCND3, GABARAP, HCST, HDAC10, IER3IP1, IL2RG, KLRK1, KRTCAP2 +11 more | |
| Innate lymphoid cells | Proteasome & COPI Trafficking Protein processing & ER | CCT8, COPE, COPZ1, COX5A, FIBP, GPX4, MDH1, NDUFC2 +5 more | View in SCUBA |
| Lymphatic endothelial | Housekeeping Mixed Housekeeping | GUK1, NDUFB11, NEDD8, PRDX5, RNASEH2C, SSR4, VPS28, ZNHIT1 | View in SCUBA |
| Macrophages | Mitochondrial OXPHOS Mitochondrial & OxPhos | ATP5IF1, ATP5MC2, ECH1, FAM89B, GMFG, GSTP1, HIGD2A, NDUFA12 +9 more | View in SCUBA |
| Mucosal-associated invariant T cell | NADPH Oxidase & Innate Immune Inflammation | ATP5F1D, ATP5MC3, COX5A, CYBA, FXYD5, GABARAP, GNG5, HIGD2A +9 more | |
| Smooth muscle cells | Mitochondrial Housekeeping Housekeeping | APP, COX7A2L, EIF5B, GABARAPL2, NDUFAB1, PGAM1, SPCS2, TMEM14C +2 more | View in SCUBA |
About the gene
| Synonyms | C7orf59 |
|---|---|
| Chromosome | 7: 100148912-100155944 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
Function
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.