HIGD2A — HIG1 hypoxia inducible domain family member 2A
HIGD2A belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HIGD2A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Actin Cytoskeleton Cytoskeletal | COTL1, GNAI2, MOB1A, MPG, MYL12A, MYL12B, NDUFB5, PRR13 +8 more | View in SCUBA |
| Endothelial | Oxidative Phosphorylation Mitochondrial & OxPhos | ATP5F1D, ATP5MC2, ATP5PO, COX7C, ERP29, HINT1, IMPDH2, LSM2 +10 more | View in SCUBA |
| Gamma-delta T cells | Mitochondrial Dynamics Mitochondrial & OxPhos | ATP5MC1, ECHS1, EDF1, FIS1, FRA10AC1, IFNAR2, MICOS13, MRI1 +2 more | |
| Goblet cells | Co-translational Chaperone Protein processing & ER | ATP5MC2, BTF3, COMMD6, FTH1, FTL, NACA, PFDN5, TOMM7 | View in SCUBA |
| Innate lymphoid cells | Proteostasis Stress Response Stress | BUB3, ERP29, GABARAPL2, NCOR1, NPM1, POLR1D, SOD1, ST13 +2 more | View in SCUBA |
| Macrophages | Mitochondrial OXPHOS Mitochondrial & OxPhos | ATP5IF1, ATP5MC2, ECH1, FAM89B, GMFG, GSTP1, LAMTOR4, NDUFA12 +9 more | View in SCUBA |
| Mucosal-associated invariant T cell | NADPH Oxidase & Innate Immune Inflammation | ATP5F1D, ATP5MC3, COX5A, CYBA, FXYD5, GABARAP, GNG5, HINT1 +9 more |
About the gene
| Synonyms | MGC2198, RCF1B |
|---|---|
| Chromosome | 5: 176388751-176389761 |
| Predicted location | Membrane |
| Essential gene | Yes |
| Protein class | Essential proteins, Metabolic proteins, Predicted membrane proteins, Transporters |
| Biological process | Electron transport, Respiratory chain, Transport |
Function
Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May be involved in cytochrome c oxidase activity. May play a role in the assembly of respiratory supercomplexes
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.