MAP4K4 — Mitogen-activated protein kinase kinase kinase kinase 4
MAP4K4 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MAP4K4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Germinal center B-cell B cell maturation | BACH2, BCL6, BPTF, GGA2, MBD4, MCTP2, MSI2, NR3C1 +7 more | View in SCUBA |
| Endothelial | Inflammatory Kinase Signaling Inflammation | ANKRD28, CBL, CDC123, CNN2, DGKH, EOGT, FADS3, FYN +7 more | View in SCUBA |
| Glial cells | ENS Developmental TFs Development | ERBIN, FRMD3, HAND2, LRRC4C, PYGL, SEC11C, SLC25A36, TBX3 +2 more | View in SCUBA |
| Goblet cells | Progenitor Identity Program Epithelial development | APEX1, FAM89B, MEX3A, NOTCH1, NREP, RNF186, SOX4, TEAD2 +3 more | View in SCUBA |
| Lymphatic endothelial | TBK1-JAK Immune Signaling Inflammation | ADAM17, AGO2, ELL2, FNIP2, IQGAP1, JAK1, NAMPT, NPC1 +6 more | View in SCUBA |
| Neutrophils | TLR2 Innate Signaling Innate immunity | AATK, CHST15, CYRIA, DHX34, ECE1, ERGIC1, MKNK1, STK40 +4 more | |
| Pericytes | ER-Actin Cytoskeletal Cytoskeletal | A2M, CSDE1, GTF2I, IQGAP1, KTN1, SEC62, SERINC1, WASF2 | View in SCUBA |
About the gene
| Synonyms | FLH21957, HGK, NIK |
|---|---|
| Chromosome | 2: 101696850-101894690 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Function
Serine/threonine kinase that plays a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway. Phosphorylates SMAD1 on Thr- 322.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.