NOTCH1 — Notch receptor 1
NOTCH1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NOTCH1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | Progenitor Identity Program Epithelial development | APEX1, FAM89B, MAP4K4, MEX3A, NREP, RNF186, SOX4, TEAD2 +3 more | View in SCUBA |
| Macrophages | Lipid-Sensing Transcriptional Lipid metabolism | ANKLE2, BAIAP2, C19orf25, C1orf52, COX19, CWC25, DEDD2, DNTTIP2 +29 more | View in SCUBA |
| Neutrophils | TLR Lipid Signaling Innate immunity | DGAT2, IFNAR1, LILRB3, MBOAT7, PPP1R3B, STEAP4, TLR1, TLR4 +1 more | |
| Pericytes | Pericyte Vascular Identity Developmental | AHR, ARHGAP29, CA4, CD46, MEF2C, MYO6, PDE1C, PLXND1 +10 more | View in SCUBA |
About the gene
| Synonyms | TAN1 |
|---|---|
| Chromosome | 9: 136494433-136546048 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters |
| Molecular function | Activator, Developmental protein, Receptor |
| Biological process | Angiogenesis, Differentiation, Notch signaling pathway, Transcription, Transcription regulation |
Function
Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.