Mitochondrial OXPHOS
Gene co-expression module in Macrophages
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 18 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 18 genes have a known function matching the annotation |
Why this annotation
ATP5MC2 and ATP5IF1 are ATP synthase subunits; NDUFA12 is a Complex I subunit; HIGD2A is a COX assembly/hypoxia-inducible factor; PRELID1 transfers phospholipids to mitochondria; ECH1 is a mitochondrial enoyl-CoA hydratase (fatty acid beta-oxidation); PRDX5 is a mitochondrial peroxiredoxin; TOMM7 is a TOM complex subunit for mitochondrial protein import. TUBA1B and PTMA are enriched in prolif_mac, suggesting a proliferation-associated peripheral component. GSTP1 (glutathione metabolism), LAMTOR4 (lysosomal mTOR), and GMFG (actin dynamics) are additional housekeeping genes. The core mitochondrial OXPHOS and import machinery signal is clear, with a minor proliferative admixture.
Genes
ATP5IF1, ATP5MC2, ECH1, FAM89B, GMFG, GSTP1, HIGD2A, LAMTOR4, NDUFA12, PGLS, PRDX5, PRELID1, PSME1, PTMA, TMEM256, TOMM7, TUBA1B, VEGFB
Most correlated modules
- Mitochondrial OXPHOS · correlation 0.96
- Mitochondrial Complex Assembly · correlation 0.91
- Oxidative Phosphorylation · correlation 0.89
- Inflammasome Oxidative Stress · correlation 0.87
- Translation Initiation · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.