FASLG — Fas ligand
FASLG belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FASLG's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytotoxic effector Cytotoxicity | ADGRG1, ATP8B4, CCL3, CCL4, CCL4L2, CSF2, GNLY, GZMB +10 more | View in SCUBA |
| Gamma-delta T cells | XCL1/XCL2 Cytotoxic Activation cytotoxicity | BCL2A1, CCL3L3, CCL4L2, ICAM1, IRF8, PLEKHO2, RILPL2, SNX18 +6 more | |
| Natural Killer cells | NK Cytotoxic Activation Cytotoxicity | CALR, CDK6, P4HB, PDIA3, PPIB, SLAMF7, STARD3NL, TIGIT +1 more | View in SCUBA |
About the gene
| Synonyms | APT1LG1, CD178, FasL, TNFSF6 |
|---|---|
| Chromosome | 1: 172659103-172666876 |
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins, Transporters |
| Molecular function | Cytokine, Repressor |
| Biological process | Apoptosis, Transcription, Transcription regulation |
Function
Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen- activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis also has a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. Induces FAS-mediated activation of NF-kappa-B, initiating non- apoptotic signaling pathways (By similarity). Can induce apoptosis but does not appear to be essential for this process. Cytoplasmic form induces gene transcription inhibition
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.