SLAMF7 — SLAM family member 7
SLAMF7 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLAMF7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Oxidative/ER stress Stress | ASAH1, ATP6V0D1, B4GALT1, FAM210A, FOSL2, GEM, GZF1, HIC1 +6 more | View in SCUBA |
| Gamma-delta T cells | ER Glycoprotein Quality Control Protein processing & ER | APOL2, BAG6, CALR, ELP3, GBP1, GBP2, GBP4, HEXB +9 more | |
| Monocytes | Tolerogenic Monocyte Activation Inflammatory | CCR5, CD40, CD80, GGT5, IDO1, IL4I1, MANF, PLA2G7 +1 more | View in SCUBA |
| Mucosal-associated invariant T cell | Vesicle Membrane Trafficking Housekeeping | ACSL5, AP2B1, APOBR, CAPRIN1, CAPZA1, DDX23, G3BP1, IARS1 +6 more | |
| Natural Killer cells | NK Cytotoxic Activation Cytotoxicity | CALR, CDK6, FASLG, P4HB, PDIA3, PPIB, STARD3NL, TIGIT +1 more | View in SCUBA |
| Neutrophils | CC Chemokine Secretion Cytokine & chemokine secretion | C15orf48, CCL20, CCL3, CCL3L3, CCL4, CCL4L2, CCRL2, CD83 +4 more |
About the gene
| Synonyms | 19A, CD319, CRACC, CS1 |
|---|---|
| Chromosome | 1: 160739057-160754821 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Receptor |
| Biological process | Adaptive immunity, Immunity, Innate immunity |
Function
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K. In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Also acts inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion. In LPS-activated monocytes negatively regulates production of pro-inflammatory cytokines. Isoform 3 does not mediate any NK cell activation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.