XCL1/XCL2 Cytotoxic Activation
Gene co-expression module in Gamma-delta T cells
| Category | cytotoxicity |
|---|---|
| Genes | 15 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 15 genes have a known function matching the annotation |
Why this annotation
XCL1 and XCL2 (lymphotactin) are the definitive chemokines produced almost exclusively by activated cytotoxic lymphocytes — particularly NK cells and γδ T cells — making them the anchor of this module. FASLG and TNFSF14 (LIGHT) are cytotoxic/pro-apoptotic effector ligands. BCL2A1 provides activation-coupled survival. CCL4L2 and CCL3L3 reinforce the inflammatory chemokine output. IRF8 is a transcription factor driving cytotoxic innate lymphoid differentiation. TRAF1 and ICAM1 support NF-κB survival signaling and adhesion during cytotoxic engagement. Module sits in a cytotoxic neighborhood with KIR+ (M182) and IFNG/CCL3 (M17) modules, confirming a coordinated activated cytotoxic effector transcriptional program in γδ T cells.
Genes
BCL2A1, CCL3L3, CCL4L2, FASLG, ICAM1, IRF8, PLEKHO2, RILPL2, SNX18, TNFSF14, TRAF1, UNC50, WIPI1, XCL1, XCL2
Most correlated modules
- Effector Cytokine Secretion · correlation 0.69
- NK-like Mature gd-T · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.