PPIB — Peptidylprolyl isomerase B

PPIB belongs to a gene co-expression module in 14 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PPIB's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Actin Cytoskeleton Cytoskeletal	ABRACL, CAPZB, CD53, CFL1, CKLF, DRAP1, GUK1, MYL12B +6 more	View in SCUBA
CD8⁺ T cells	ER Protein Quality Control Protein processing & ER	ARPC3, CALR, DYNLL1, MRPL47, PDIA3, PSMA5, PSMB1, PSMC4 +3 more	View in SCUBA
Endothelial	ER Protein Processing Protein processing & ER	AP2S1, ATOX1, C1QBP, CCT3, DBI, ENO1, NHP2, OSTC +5 more	View in SCUBA
Fibroblasts	ER Secretory Processing Housekeeping	DAD1, ELOB, FKBP1A, MYL12B, POLR2L, RABAC1, SPCS1, SSR4 +2 more	View in SCUBA
Gamma-delta T cells	Protein Homeostasis Chaperones Housekeeping	ATXN10, DYNLRB1, GMFG, HIGD1A, NAA10, POLR2J, PPIA, PRDX2 +6 more
Glial cells	ER Translocon Activity Protein processing & ER	ARPC2, CALR, EDF1, MRPL52, MYL6, NDUFA1, OST4, PFN1 +3 more	View in SCUBA
Goblet cells	Mucin Folding Machinery Mucus production & secretion	AGR2, KDELR2, MYDGF, OSTC, SEC11C, SEC61B, SEC61G, SSR3	View in SCUBA
Hematopoietic progenitor cells	ER Protein Folding Housekeeping	ASRGL1, CALR, CD63, CHPT1, EMP3, GLUL, HSPA5, IDH2 +13 more
Innate lymphoid cells	Glycolysis & OxPhos Metabolism	ANXA7, ARF3, ATP5MC3, CD320, CD74, CNBP, COX6A1, COX6B1 +10 more	View in SCUBA
Macrophages	ER Protein Glycosylation Vesicular traficking	AK2, ALG3, ALG5, BABAM1, CKLF, CRELD2, DDOST, DPM3 +21 more	View in SCUBA
Mucosal-associated invariant T cell	Cyclophilin-Mediated Folding Housekeeping	B2M, BBLN, BCL7C, C12orf75, CFL1, EDF1, EIF3L, ERH +10 more
Natural Killer cells	NK Cytotoxic Activation Cytotoxicity	CALR, CDK6, FASLG, P4HB, PDIA3, SLAMF7, STARD3NL, TIGIT +1 more	View in SCUBA
Pericytes	ER Protein Folding Stress	AP2S1, CALU, DYNLT1, IKBIP, KDELR2, MYDGF, OSTC, P4HB +1 more	View in SCUBA
Smooth muscle cells	ER Chaperone/UPR Protein processing & ER	CALR, CRISPLD2, FBLIM1, HIF1A, HSP90B1, HSPA5, IL6ST, OSMR +3 more	View in SCUBA

About the gene

Synonyms	B, CYP-S1, CYPB, OI9, PPIase, SCYLP
Chromosome	15: 64155740-64163134
Predicted location	Intracellular, Secreted
Essential gene	No
Protein class	Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins
Molecular function	Isomerase, Rotamase

Function

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.