FCGR3B — Fc gamma receptor IIIb
FCGR3B belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FCGR3B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Monocytes | Macrophage Differentiation Developmental | C7orf50, CABP4, FMNL2, IL3RA, MS4A4A, MSR1, PPM1N, PPP1R17 +3 more | View in SCUBA |
| Neutrophils | Neutrophil Chemotaxis Receptors Chemotaxis | CEBPD, CXCR1, CXCR2, EVI2B, FCGR3A, NRBF2, WAS, YPEL3 |
About the gene
| Synonyms | CD16, CD16b, FCG3, FcgammaRIIIb, FCGR3, FcRIIIb |
|---|---|
| Chromosome | 1: 161623196-161631963 |
| Predicted location | Intracellular, Membrane, Secreted |
| Essential gene | No |
| Protein class | CD markers, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters |
| Molecular function | IgG-binding protein, Receptor |
Function
Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.