WAS — WASP actin nucleation promoting factor
WAS belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
WAS's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | ER-Golgi Trafficking Protein processing & ER | ALG5, CNIH4, HDDC3, KDELR1, ORMDL2, PYCARD, RAB8A, RASAL3 +4 more | View in SCUBA |
| Gamma-delta T cells | Actin Remodeling Cytoskeletal | AP1M1, APOBEC3C, ATP5PB, CAP1, CAPN1, CAPZB, DBNL, LSP1 +10 more | |
| Innate lymphoid cells | ILC1 Lymphocyte Signaling Immune regulation | CDIPT, CNPY3, DBNL, ENG, IL16, LIMD2, LSM2, MAPKAPK3 +11 more | View in SCUBA |
| Macrophages | RNA Processing & Repair Housekeeping | BRD7, CCDC59, CCT4, CCT6A, CNDP2, EIF3J, EIF5B, EMC4 +31 more | View in SCUBA |
| Mucosal-associated invariant T cell | Actin Cytoskeletal Remodeling Cytoskeletal | ANXA6, CAP1, CASP1, CCT5, CCT6A, DEF6, FGD3, GIMAP6 +7 more | |
| Neutrophils | Neutrophil Chemotaxis Receptors Chemotaxis | CEBPD, CXCR1, CXCR2, EVI2B, FCGR3A, FCGR3B, NRBF2, YPEL3 |
About the gene
| Synonyms | IMD2, THC, WASP, WASPA |
|---|---|
| Chromosome | X: 48676596-48691431 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins |
Function
Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria. In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.