IL3RA — Interleukin 3 receptor subunit alpha
IL3RA belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IL3RA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Immune Cell Contamination Cell contamination | ANKRD65, CADM1, CD79B, CLEC1A, JDP2, KAZN, MYH11, MYLK +2 more | View in SCUBA |
| Fibroblasts | FRC function Immune interaction | ADRA2A, ANKRD29, CCL19, CCL21, CTSH, GP1BA, KCNK13, NPB +3 more | View in SCUBA |
| Macrophages | NRF2 Oxidative Stress Stress | ACOT9, AHRR, ARMC9, BASP1, CARD19, CCDC71L, CD226, CLDND1 +27 more | View in SCUBA |
| Monocytes | Macrophage Differentiation Developmental | C7orf50, CABP4, FCGR3B, FMNL2, MS4A4A, MSR1, PPM1N, PPP1R17 +3 more | View in SCUBA |
| Pericytes | BMP-SMAD Signaling Developmental | CTSH, ETS2, EXOC3L2, ITM2A, MCF2L, NDST1, PDE2A, SCARB1 +3 more | View in SCUBA |
About the gene
| Synonyms | CD123 |
|---|---|
| Chromosome | X: 1336616-1382689 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Receptor |
Function
Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.