FOXM1 — Forkhead box M1
FOXM1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FOXM1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | FOXM1-driven G2/M Cell cycle | CENPW, MKI67, NCAPG, NDC80, NEIL3, PBK, RCCD1 | View in SCUBA |
| Goblet cells | FOXM1-driven G2/M Cell cycle | CDCA5, CENPK, DIAPH3, E2F8, ESCO2, IQGAP3, MELK, ORC6 +5 more | View in SCUBA |
About the gene
| Synonyms | FKHL16, HFH-11, HNF-3, INS-1, MPHOSPH2, MPP2, TGT3, trident |
|---|---|
| Chromosome | 12: 2857680-2877174 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | Cell cycle, DNA damage, DNA repair, Transcription, Transcription regulation |
Function
Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Also plays a role in DNA break repair, participating in the DNA damage checkpoint response. Promotes transcription of PHB2.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.