E2F8 — E2F transcription factor 8
E2F8 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
E2F8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | DNA Replication Cell cycle | ATAD2, ATAD5, BRCA1, CDCA4, ESCO2, FANCI, FBXO5, LIG1 +4 more | View in SCUBA |
| CD8⁺ T cells | S-phase Replication Cell cycle | ATAD2, CEP152, E2F7, ESCO2, FAM111A, NCAPD3, POLQ, STIL | View in SCUBA |
| Goblet cells | FOXM1-driven G2/M Cell cycle | CDCA5, CENPK, DIAPH3, ESCO2, FOXM1, IQGAP3, MELK, ORC6 +5 more | View in SCUBA |
About the gene
| Synonyms | FLJ23311 |
|---|---|
| Chromosome | 11: 19224063-19241620 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding, Repressor |
| Biological process | Cell cycle, Transcription, Transcription regulation |
Function
Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.