CENPW — Centromere protein W
CENPW belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CENPW's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Cell Cycle Proliferation Cell cycle | ALYREF, ANP32E, BCL2L12, BIRC5, BUB3, CEP55, CKS1B, DTYMK +4 more | View in SCUBA |
| CD8⁺ T cells | FOXM1-driven G2/M Cell cycle | FOXM1, MKI67, NCAPG, NDC80, NEIL3, PBK, RCCD1 | View in SCUBA |
| Endothelial | Mitotic Cell Cycle Cell cycle | ANP32E, BIRC5, CENPN, CKS1B, DTYMK, GGH, PRR11, PTTG1 +3 more | View in SCUBA |
| Fibroblasts | Neural-crest Fibroblast Developmental | AMIGO2, C1orf54, DCLK1, FLRT2, FOXP2, IGFBP4, KIAA0408, MAOB +8 more | View in SCUBA |
| Hematopoietic progenitor cells | Mitotic Spindle Checkpoint Cell cycle | CENPF, CKS1B, GGH, HMGB2, MAD2L1, PTTG1, UBE2T, ZWINT | |
| Macrophages | Mitotic Spindle Assembly Cell cycle | ACTL6A, AKR7A2, ANP32E, BOLA3, BUB3, CCDC167, CENPX, DCTPP1 +34 more | View in SCUBA |
| Smooth muscle cells | SMC Ion Signaling Contractility | ANTXR2, ATP1B1, CDKN1C, FAM83D, FXYD6, GAS1, KCNMA1, LRIG1 +12 more | View in SCUBA |
About the gene
| Synonyms | C6orf173, CUG2 |
|---|---|
| Chromosome | 6: 126340115-126348875 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | DNA-binding |
| Biological process | Cell cycle, Cell division, Mitosis |
Function
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.