FOXM1-driven G2/M
Gene co-expression module in Goblet cells
| Category | Cell cycle |
|---|---|
| Genes | 14 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 14 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes: CDCA5 (sororin, cohesin regulator), RAD51AP1 (homologous recombination), RRM2 (ribonucleotide reductase, S-phase), MELK (mitotic kinase), ZWINT (kinetochore), DIAPH3 (cytokinesis formin), ESCO2 (cohesion establishment), E2F8 (transcription factor driving S-phase genes), CENPK (kinetochore), ORC6 (origin recognition complex), SPC25 (kinetochore), FOXM1 (master mitotic transcription factor), IQGAP3 (mitotic scaffold), SHCBP1 (spindle midzone). FOXM1 and E2F8 are canonical transcriptional drivers of the G2/M gene program. RRM2 and ORC6 indicate S-phase activity. All genes are core and uniform. Coherence is core. Strongly S/G2-M cell cycle, with emphasis on the FOXM1-driven transcriptional program. Neighbor context (M42, M25, M62, M43) all confirm a cell cycle cluster.
Genes
CDCA5, CENPK, DIAPH3, E2F8, ESCO2, FOXM1, IQGAP3, MELK, ORC6, RAD51AP1, RRM2, SHCBP1, SPC25, ZWINT
Most correlated modules
- S/G2 Preparation · correlation 0.91
- Chromosome Segregation · correlation 0.88
- S-phase DNA Replication · correlation 0.86
- Replication Fork Checkpoint · correlation 0.83
- Mitotic Proliferation · correlation 0.83
- Spliceosome Assembly · correlation 0.80
- Mitotic Spindle Assembly · correlation 0.76
- Chromatin Remodeling Repair · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.