FOXM1-driven G2/M
Gene co-expression module in CD8⁺ T cells
| Category | Cell cycle |
|---|---|
| Genes | 8 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
NCAPG (condensin I subunit, chromosome condensation); RCCD1 (RCC domain-containing, centrosomal/mitotic); FOXM1 (master transcription factor driving G2/M gene expression, canonical proliferation marker); PBK (PDZ-binding kinase, mitosis-specific kinase activated by CDK1); NEIL3 (DNA glycosylase, replication-associated repair); CENPW (kinetochore protein, CENP-T/W complex); NDC80 (kinetochore, kinetochore-microtubule attachment); MKI67 (Ki-67, canonical proliferation marker expressed in all active phases of cell cycle). FOXM1 as a hub is particularly informative — it transcriptionally drives many of the other genes in this module. This module represents the FOXM1-driven G2/M transcriptional program, distinguished from M77 by having a clear transcription factor driver.
Genes
CENPW, FOXM1, MKI67, NCAPG, NDC80, NEIL3, PBK, RCCD1
Most correlated modules
- Mitosis & Cytokinesis · correlation 0.99
- CDK1-Aurora Kinase Mitosis · correlation 0.98
- Mitotic Spindle Assembly · correlation 0.98
- Spindle Bipolarity Cytokinesis · correlation 0.97
- G2/M Cell Cycle · correlation 0.96
- S-phase Chromatin Replication · correlation 0.95
- Mitotic Spindle · correlation 0.95
- Mitotic Spindle · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.