PBK — PDZ binding kinase
PBK belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PBK's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Mitotic Spindle Cell cycle | AURKB, CCNA2, CDCA3, CDCA8, CDK1, KIF2C, NDC80, NUF2 +3 more | View in SCUBA |
| CD8⁺ T cells | FOXM1-driven G2/M Cell cycle | CENPW, FOXM1, MKI67, NCAPG, NDC80, NEIL3, RCCD1 | View in SCUBA |
| Goblet cells | Mitotic Proliferation Cell cycle | BIRC5, CCNA2, KIF20B, MKI67, RACGAP1, TOP2A, TPX2 | View in SCUBA |
About the gene
| Synonyms | CT84, FLJ14385, Nori-3, SPK, TOPK |
|---|---|
| Chromosome | 8: 27809624-27838082 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Function
Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin- induced DNA damage.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.