ESCO2 — Establishment of sister chromatid cohesion N-acetyltransferase 2
ESCO2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ESCO2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | DNA Replication Cell cycle | ATAD2, ATAD5, BRCA1, CDCA4, E2F8, FANCI, FBXO5, LIG1 +4 more | View in SCUBA |
| CD8⁺ T cells | S-phase Replication Cell cycle | ATAD2, CEP152, E2F7, E2F8, FAM111A, NCAPD3, POLQ, STIL | View in SCUBA |
| Goblet cells | FOXM1-driven G2/M Cell cycle | CDCA5, CENPK, DIAPH3, E2F8, FOXM1, IQGAP3, MELK, ORC6 +5 more | View in SCUBA |
About the gene
| Synonyms | EFO2, RBS |
|---|---|
| Chromosome | 8: 27771949-27812640 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Acyltransferase, Transferase |
| Biological process | Cell cycle |
Function
Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.