Vesicular Trafficking
Gene co-expression module in Gamma-delta T cells
| Category | Housekeeping |
|---|---|
| Genes | 19 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 19 genes have a known function matching the annotation |
Why this annotation
Hub genes RAB6A, TGOLN2, COPG1, and EXOC7 point strongly to Golgi/vesicular trafficking. Additional genes ADD1 and TLN1 reflect cytoskeletal scaffolding, GANAB is a glycoprotein-processing glucosidase in the ER/Golgi, and TMEM30A is a phospholipid flippase. MED1/MED23 and ANAPC5 are ancillary. Uniform expression across all subsets and moderate pct positive (~26%) is consistent with a housekeeping intracellular trafficking program rather than a cell-type-specific or disease-driven module.
Genes
ADD1, ANAPC5, COPG1, EFCAB14, EXOC7, GANAB, MAN2B2, MCM3AP, MED1, MED23, RAB6A, RNPC3, SLC30A7, TGOLN2, TLN1, TMEM30A, UHMK1, VHL, ZNF664
Most correlated modules
- ER Antigen Processing · correlation 0.90
- Chromatin Epigenetic Regulation · correlation 0.89
- Chromatin Remodeling · correlation 0.88
- mTOR-Exocyst Signaling · correlation 0.86
- Actin Cytoskeletal Regulation · correlation 0.86
- Hippo Pathway Signaling · correlation 0.84
- Metabolic-Translational Coupling · correlation 0.84
- DNA Damage Response · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.