NOLC1 — Nucleolar and coiled-body phosphoprotein 1
NOLC1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NOLC1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Heat Shock Response Stress | BCLAF1, CCNL1, CHORDC1, CLK1, FAM133B, GADD45B, HSPH1, IER5 +5 more | View in SCUBA |
| Gamma-delta T cells | Metabolic-Translational Coupling RNA processing & translation | APOL6, ARCN1, ARGLU1, DCAF12, DDX23, EIF2S1, EIF4G1, FHOD1 +20 more | |
| Hematopoietic progenitor cells | Ribosome Biogenesis Housekeeping | DDX21, DKC1, GNL3, HNRNPAB, LRPPRC, NOP56, NOP58, PA2G4 +2 more | |
| Macrophages | Replication Chromatin Assembly Cell cycle | ANP32B, CBX3, CDK4, COPS3, DEK, DNMT1, EMC8, EXOSC8 +22 more | View in SCUBA |
| Mucosal-associated invariant T cell | Nuclear-Cytoskeletal Organization Housekeeping | DDB1, GANAB, HYOU1, IPO7, MYH9, NUMA1, PRPF8, SIN3A +4 more | |
| Smooth muscle cells | STAT3 transcriptional program Activation | DDX3X, FAM210B, HLA-E, HNRNPH1, ID4, ITPR1, RAB21, STAT3 +2 more | View in SCUBA |
About the gene
| Synonyms | KIAA0035, NOPP130, NOPP140, P130, Srp40 |
|---|---|
| Chromosome | 10: 102152176-102163871 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Plasma proteins, Predicted intracellular proteins |
Function
Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification. Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. It has intrinsic GTPase and ATPase activities.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.