Nuclear-Cytoskeletal Organization
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Housekeeping |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 13 genes have a known function matching the annotation |
Why this annotation
This highly coherent (core) module contains NUMA1 (nuclear mitotic apparatus protein, spindle pole organization), MYH9 (non-muscle myosin IIA, actomyosin cytoskeleton), SPTAN1 (spectrin alpha, cortical cytoskeleton), NOLC1 (nucleolar protein, rRNA processing), TAF15 (RNA Pol II general TF), PRPF8 (core spliceosome component), DDB1 (DNA damage recognition, CRL4 E3 ligase), SIN3A (HDAC-associated transcriptional repressor), TASOR (HUSH complex, epigenetic silencing), IPO7 (importin 7, nuclear import of large proteins including histones), HYOU1 (ER chaperone/UPR), and GANAB (ER glucosidase). The module unifies large structural nuclear/cytoskeletal proteins with RNA processing and chromatin repression machinery — characteristic of a housekeeping large-protein cellular organization program. The tightness (all core/strong membership) supports a shared expression program in proliferating or activated T cells.
Genes
DDB1, GANAB, HYOU1, IPO7, MYH9, NOLC1, NUMA1, PRPF8, SIN3A, SPTAN1, TAF15, TASOR, ZZEF1
Most correlated modules
- SWI/SNF Chromatin Remodeling · correlation 0.86
- T cell Activation Signaling · correlation 0.85
- Co-transcriptional Splicing · correlation 0.84
- Cytoskeletal Organization · correlation 0.81
- Cellular Maintenance · correlation 0.77
- mRNA Processing Translation · correlation 0.77
- Circadian Transcriptional Regulation · correlation 0.75
- Transcription Factor Activity · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.