GLO1 — Glyoxalase I
GLO1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GLO1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Gamma-delta T cell Cell contamination | ABHD15, ANKRD28, APOBR, CLIC3, CLIC5, EGLN3, ELOVL6, NBL1 +9 more | View in SCUBA |
| Innate lymphoid cells | mTOR Metabolic Stress Stress | ADPGK, AKR1A1, ATP5IF1, BAX, CPNE1, GSTO1, HNRNPR, JAGN1 +9 more | View in SCUBA |
| Macrophages | MMP-driven ECM Remodeling ECM remodeling | A4GALT, ACP5, ASB2, ASMTL, ATP6V0D2, BID, CFP, CPOX +12 more | View in SCUBA |
About the gene
| Synonyms | GLOD1 |
|---|---|
| Chromosome | 6: 38675925-38703145 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Lyase |
Function
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.