mTOR Metabolic Stress
Gene co-expression module in Innate lymphoid cells
| Category | Stress |
|---|---|
| Genes | 18 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 18 genes have a known function matching the annotation |
Why this annotation
LAMTOR2 (Ragulator complex, mTORC1 lysosomal anchoring) is the top core hub gene, directly linking this module to mTOR signaling. GSTO1 (glutathione S-transferase omega), GLO1 (glyoxalase I — methylglyoxal detoxification), and AKR1A1 (aldo-keto reductase) indicate oxidative/carbonyl stress response. BAX suggests apoptotic priming. LSM4 and HNRNPR are RNA processing factors. ATP5IF1 inhibits ATP synthase under stress. The combination of mTOR pathway, oxidative stress detoxification, and RNA processing suggests a metabolic stress/mTOR-regulated program. Moderate coherence with many weak members reflects mixed sub-programs.
Genes
ADPGK, AKR1A1, ATP5IF1, BAX, CPNE1, GLO1, GSTO1, HNRNPR, JAGN1, LAMTOR2, LSM4, MCRIP1, PIN4, RAD23A, TCF25, THRAP3, VBP1, YIF1A
Most correlated modules
- Mitochondrial OxPhos Biogenesis · correlation 0.95
- Lipid & Isoprenoid Metabolism · correlation 0.95
- Proteasome & COPI Trafficking · correlation 0.95
- Mitochondrial Metabolism · correlation 0.95
- Proteasome & TCA · correlation 0.94
- Mitochondrial Lysosomal Housekeeping · correlation 0.94
- Mitochondrial OxPhos · correlation 0.94
- Mixed Proteostasis Metabolism · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.