IL33 — Interleukin 33
IL33 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IL33's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | IL33 Alarmin Signaling Inflammation | ARHGAP26, CHN1, DOC2B, MCUB, PTAFR, SDCBP, SLC8A1, STMN3 +1 more | View in SCUBA |
| Fibroblasts | BMP-antagonizing Fibroblast Developmental | AP1S2, GREM1, HSPB6, MBP, NBEA, PBX3, RGMA, RGN +1 more | View in SCUBA |
| Lymphatic endothelial | IL33 Alarmin Response Inflammation | CLIC4, EPAS1, HRCT1, IGFBP5, LIFR, PLAT, PLSCR1, PRELP +4 more | View in SCUBA |
About the gene
| Synonyms | C9orf26, DKFZp586H0523, DVS27, IL1F11, NF-HEV |
|---|---|
| Chromosome | 9: 6215786-6257983 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Cytokine |
| Biological process | Transcription |
Function
Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2- associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as an enhancer of polarization of alternatively activated macrophages. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury. Induces rapid UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (By similarity). In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or pro- inflammatory activation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.