BMP-antagonizing Fibroblast
Gene co-expression module in Fibroblasts
| Category | Developmental |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
GREM1 is a canonical marker of subepithelial myofibroblasts/telocytes in the intestinal crypt niche, where it antagonizes BMP signaling to support stem cells. RGMA is another BMP pathway modulator. IL33 is an alarmin produced by stromal cells. PBX3 and NBEA add transcriptional/signaling context. The module is downregulated in inflammation and upregulated in remission, consistent with a homeostatic BMP-antagonizing subepithelial fibroblast identity.
Genes
AP1S2, GREM1, HSPB6, IL33, MBP, NBEA, PBX3, RGMA, RGN, TPD52L1
Most correlated modules
- Neural-crest Fibroblast · correlation 0.89
- Wnt-niche Fibroblast · correlation 0.86
- Submucosal Fibroblast · correlation 0.85
- Subepithelial Fibroblast Identity · correlation 0.75
- Complement-producing Fibroblast · correlation 0.72
- Quiescent Stromal Identity · correlation 0.69
- Inflammation-activated ECM · correlation 0.65
- Elastin-Fibronectin ECM · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.