RGMA — Repulsive guidance molecule BMP co-receptor a
RGMA belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RGMA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | BMP-antagonizing Fibroblast Developmental | AP1S2, GREM1, HSPB6, IL33, MBP, NBEA, PBX3, RGN +1 more | View in SCUBA |
| Smooth muscle cells | Microfibrillar ECM Program ECM remodeling | ALDH1A1, CDC42EP3, FGL2, FOXP2, MAB21L2, MFAP2, NREP, OLFML3 +2 more | View in SCUBA |
About the gene
| Synonyms | RGM |
|---|---|
| Chromosome | 15: 93035271-93089211 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted secreted proteins |
Function
Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA- ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG- PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1- AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.