Venous Endothelial Identity
Gene co-expression module in Endothelial
| Category | Endothelial cell development |
|---|---|
| Genes | 20 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 20 genes have a known function matching the annotation |
Why this annotation
This module contains multiple canonical venous/endothelial identity markers: EMCN (endomucin, a defining marker of venous endothelium), NOTCH4 (endothelial-specific Notch receptor critical for arteriovenous specification), ACE (angiotensin-converting enzyme, expressed on pulmonary and venous endothelium), FLT1/VEGFR1 (VEGF receptor expressed on endothelium), UNC5B (netrin receptor guiding vascular patterning), HLX (homeobox transcription factor expressed in endothelium), VSIR (immune checkpoint molecule on endothelium), and ITGA1 (integrin alpha-1). GSN (gelsolin) regulates actin dynamics. The module is significantly decreased during inflammation and recovers in remission, consistent with loss of homeostatic endothelial identity during IBD. The combination of EMCN, NOTCH4, ACE, and FLT1 makes this a high-confidence venous endothelial identity module.
Genes
ACE, ADARB1, CDC42EP1, CLSTN1, EMCN, FLT1, GALNT18, GPRC5B, GSN, HLX, ITGA1, MCC, NCALD, NCOA3, NOTCH4, RAPGEF2, SEC14L1, STK10, UNC5B, VSIR
Most correlated modules
- Endothelial Lipid Signaling · correlation 0.90
- Caveolae-mediated Transcytosis · correlation 0.86
- Capillary Endothelial Identity · correlation 0.86
- Endothelial Junction Identity · correlation 0.83
- Mitophagy Stress Response · correlation 0.81
- Glucocorticoid Response · correlation 0.79
- Angiogenic Endothelial Identity · correlation 0.79
- Integrin-Actin Adhesion · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.