HOOK2 — Hook microtubule tethering protein 2
HOOK2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HOOK2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Naive resting T cell T cell development | ACTN1, ADD3, ALKBH7, ANKRD55, ARMH1, CEP170, EDAR, GCNT4 +7 more | View in SCUBA |
| Gamma-delta T cells | ER Protein Translocation Protein processing & ER | ATG2A, BEST1, CLSTN1, CTDSP2, GALC, GSE1, HAPSTR1, KMT2E +12 more | |
| Mucosal-associated invariant T cell | RNA Splicing m6A RNA processing & translation | ARF1, ARF6, ATP5F1B, CIRBP, CORO7, EIF1B, EIF5A, EMD +15 more |
About the gene
| Synonyms | HK2 |
|---|---|
| Chromosome | 19: 12763003-12872740 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Protein transport, Transport |
Function
Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.