CTDSP2 — CTD small phosphatase 2
CTDSP2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CTDSP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | ER Protein Translocation Protein processing & ER | ATG2A, BEST1, CLSTN1, GALC, GSE1, HAPSTR1, HOOK2, KMT2E +12 more | |
| Smooth muscle cells | Atrophy Proteolysis Program Stress | ARL6IP5, FBXO32, FOXP1, GLUL, SERINC3, SQSTM1, UBE2B | View in SCUBA |
About the gene
| Synonyms | OS4, PSR2, SCP2 |
|---|---|
| Chromosome | 12: 57819927-57846729 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protein phosphatase |
Function
Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.