RNA Splicing m6A
Gene co-expression module in Mucosal-associated invariant T cell
| Category | RNA processing & translation |
|---|---|
| Genes | 24 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 24 genes have a known function matching the annotation |
Why this annotation
MAGOH (exon junction complex), WTAP (m6A RNA methylation writer), SF3B5 (splicing factor), CIRBP (stress-induced RNA binding protein), EIF5A (translation elongation factor, hypusination-dependent), EIF1B (translation initiation) together form an RNA processing and post-transcriptional regulation core. SOCS3 provides cytokine feedback. ARF1/ARF6 contribute vesicle trafficking. This is primarily an RNA processing module with stress-induced post-transcriptional regulatory components.
Genes
ARF1, ARF6, ATP5F1B, CIRBP, CORO7, EIF1B, EIF5A, EMD, GUK1, HMGB1, HOOK2, MAGOH, MATR3, MORF4L1, ORAI1, PNPLA2, POMP, RSRP1, SERP1, SF3B5, SOCS3, UBE2B, WTAP, ZC3H15
Most correlated modules
- NF-κB Activation · correlation 0.85
- PI3K MAPK Signaling · correlation 0.85
- ER Stress UPR · correlation 0.83
- NF-κB RNA Regulation · correlation 0.79
- Dissociation Stress Response · correlation 0.77
- Housekeeping Translation · correlation 0.74
- TGF-beta Response · correlation 0.67
- AP-1 Immediate Early · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.