GALC — Galactosylceramidase
GALC belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GALC's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | ER Protein Translocation Protein processing & ER | ATG2A, BEST1, CLSTN1, CTDSP2, GSE1, HAPSTR1, HOOK2, KMT2E +12 more | |
| Hematopoietic progenitor cells | Myeloid Lipid Signaling Myeloid development | AFF2, CLEC12A, PLD1, SGPP1, SLC24A3, TENT5A, TEX9 | |
| Macrophages | Myeloid Innate Signaling Innate immunity | ADCY7, ARHGAP18, BMP2K, C3AR1, C6orf62, CD46, CD84, CLTC +34 more | View in SCUBA |
| Mucosal-associated invariant T cell | Post-translational Regulation Housekeeping | CCDC93, CD55, FBXO33, KCTD20, KDM2B, MGAT4A, MSL2, PDE4D +8 more |
About the gene
| Chromosome | 14: 87837820-87993665 |
|---|---|
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Glycosidase, Hydrolase |
| Biological process | Lipid degradation, Lipid metabolism, Sphingolipid metabolism |
Function
Hydrolyzes the galactose ester bonds of glycolipids such as galactosylceramide and galactosylsphingosine. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.