ER Protein Translocation
Gene co-expression module in Gamma-delta T cells
| Category | Protein processing & ER |
|---|---|
| Genes | 21 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 21 genes have a known function matching the annotation |
Why this annotation
SRPRA encodes the signal recognition particle receptor alpha subunit, essential for co-translational protein targeting to the ER. SPCS3 is a signal peptidase complex subunit that cleaves signal peptides in the ER lumen. SEC61A1 encodes the main translocon channel for protein import into the ER. RAB18 localizes to the ER and lipid droplets. ATG2A is involved in autophagosome formation linked to ER membranes. POM121C is a nuclear pore component involved in nuclear-ER connectivity. SETD1B and KMT2E are histone methyltransferases. HOOK2 links endosomes to cytoskeleton. The dominant theme is ER protein translocation and secretory pathway components.
Genes
ATG2A, BEST1, CLSTN1, CTDSP2, GALC, GSE1, HAPSTR1, HOOK2, KMT2E, MFSD11, NEO1, PHF12, POM121C, RAB18, SEC61A1, SETD1B, SNRK, SPCS3, SRPRA, TMEM263, TMEM71
Most correlated modules
- mRNA Splicing Processing · correlation 0.82
- T Cell Exhaustion · correlation 0.80
- Translation & Proteostasis · correlation 0.80
- Circadian Clock · correlation 0.79
- T cell Identity Signaling · correlation 0.78
- TCR-Cytokine Signaling · correlation 0.78
- Innate Stress Signaling · correlation 0.75
- gd T Cell Identity · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.