SCUBA

NDUFA1 — NADH:ubiquinone oxidoreductase subunit A1

NDUFA1 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

NDUFA1's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsProtein/ER secretory machinery
Protein processing & ER
ACTR2, ATP5IF1, ATP5ME, BAZ1B, CMC2, CNPY2, COMMD3, COPZ1 +16 moreView in SCUBA
EnterocytesOxidative Phosphorylation
Mitochondrial & OxPhos
COX6A1, COX6C, DDT, ECHS1, HADHA, LGALS4, MGST3, PRDX1 +3 moreView in SCUBA
Gamma-delta T cellsOxidative Phosphorylation
Mitochondrial & OxPhos
ARPC1B, ARPC4, ATP6V1F, COPE, COX6A1, COX6B1, COX6C, CSNK2B +12 more
Glial cellsER Translocon Activity
Protein processing & ER
ARPC2, CALR, EDF1, MRPL52, MYL6, OST4, PFN1, PPIB +3 moreView in SCUBA
Goblet cellsGoblet Cell Identity
Mucus production & secretion
AGR3, CA12, CD9, FAM162A, IL1R2, LGALS4, SCP2, TMEM141 +1 moreView in SCUBA
Innate lymphoid cellsProteasome & TCA
Protein processing & ER
ACP1, ARPC5L, CAPZA1, CLTA, COPS9, HDAC1, MDH2, NUDT16L1 +5 moreView in SCUBA
Lymphatic endothelialMitochondrial OxPhos Complex
Mitochondrial & OxPhos
COX6A1, COX6B1, COX6C, COX7A2, COX8A, DAD1, NDUFB4, NDUFB5 +6 moreView in SCUBA
MacrophagesMitochondrial OXPHOS
Mitochondrial & OxPhos
APRT, ARPC3, ATP5F1E, ATP5MF, ATP5MG, BLOC1S1, BTF3, CLTB +28 moreView in SCUBA
Mucosal-associated invariant T cellATP Synthase Complex
Mitochondrial & OxPhos
ARL6IP4, ATP5F1E, ATP5ME, ATP5MK, COMMD6, COPS9, COX7C, HAX1 +3 more

About the gene

SynonymsCI-MWFE, MWFE
ChromosomeX: 119871832-119876662
Predicted locationMembrane
Essential geneNo
Protein classDisease related genes, Human disease related genes, Metabolic proteins, Predicted membrane proteins
Biological processElectron transport, Respiratory chain, Transport

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.