AGR3 — Anterior gradient 3, protein disulphide isomerase family member
AGR3 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AGR3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Surface colonocyte differentiation Epithelial development | ATP1B1, BMP3, CLDN3, DSP, KLF5, KRT20, NEURL1B, PDLIM1 +2 more | View in SCUBA |
| Goblet cells | Goblet Cell Identity Mucus production & secretion | CA12, CD9, FAM162A, IL1R2, LGALS4, NDUFA1, SCP2, TMEM141 +1 more | View in SCUBA |
About the gene
| Synonyms | BCMP11, hAG-3, HAG3, PDIA18 |
|---|---|
| Chromosome | 7: 16859412-16881987 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.