ISG20L2 — Interferon stimulated exonuclease gene 20 like 2
ISG20L2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ISG20L2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TRIM28-ZNF Repression DNA/chromatin regulation | B4GALT4, EEA1, FSCN1, HSPA2, MAP3K13, MLF1, MORN3, PABPC4 +7 more | View in SCUBA |
| Gamma-delta T cells | Transcription-RNA Coupling DNA/chromatin regulation | AKNA, AP1G1, BTAF1, BZW1, CRNKL1, DDX6, DNTTIP2, DYNC1H1 +26 more | |
| Macrophages | Nuclear Pore Transport Housekeeping | AARS1, APH1A, ARF3, ATG3, CNOT7, CTDNEP1, DCAF7, GNAI2 +18 more | View in SCUBA |
About the gene
| Synonyms | FLJ12671 |
|---|---|
| Chromosome | 1: 156721891-156728766 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | Exonuclease, Hydrolase, Nuclease |
| Biological process | Ribosome biogenesis |
Function
3'-> 5'-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3'-end containing a free hydroxyl group
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.