APH1A — Aph-1 homolog A, gamma-secretase subunit
APH1A belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
APH1A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Proteasome Complex Protein processing & ER | EIF3I, JTB, MRPL27, PSMB6, PSMB7, PSMC1, PSMC3, PSMC4 +4 more | |
| Innate lymphoid cells | Cellular Metabolic Maintenance Metabolism | ADIPOR1, ARF5, BCAP31, CLIC1, CSNK2B, CYB5R3, DHPS, ERGIC3 +13 more | View in SCUBA |
| Macrophages | Nuclear Pore Transport Housekeeping | AARS1, ARF3, ATG3, CNOT7, CTDNEP1, DCAF7, GNAI2, HCFC1 +18 more | View in SCUBA |
| Mucosal-associated invariant T cell | PI3K MAPK Signaling TCR Signaling | AKT1, BRD4, CALM2, CMTM3, DAZAP1, GNAS, GRK2, MAP2K2 +11 more |
About the gene
| Synonyms | APH-1A, CGI-78 |
|---|---|
| Chromosome | 1: 150265399-150269580 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Transporters |
| Biological process | Notch signaling pathway |
Function
Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Required for normal gamma-secretase assembly. The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.