Nuclear Pore Transport
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 27 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 13 of 27 genes have a known function matching the annotation |
Why this annotation
Top hub NUP62 is a core nuclear pore complex component mediating nucleocytoplasmic transport. Supporting genes include CTDNEP1 (nuclear envelope phosphatase), HCFC1 (nuclear transcription coactivator), SUZ12 (PRC2 Polycomb epigenetic silencing), CNOT7 (CCR4-NOT mRNA deadenylase/decay), KHSRP (mRNA decay/splicing), HNRNPUL2 (RNA-binding), SYNCRIP (RNA-binding), PTBP1 (splicing repressor), ARF3 (ADP-ribosylation factor, vesicular), VPS35 (retromer endosomal recycling), RAB14 (endosomal trafficking), SCAMP2 (secretory carrier membrane), GNAI2 (G-protein). The module combines nuclear transport (NUP62, CTDNEP1) with RNA processing (KHSRP, SYNCRIP, PTBP1, HNRNPUL2) and endosomal recycling (VPS35, RAB14, ARF3). As a neighbor to M80 (splicing) and M29 (vesicular), this module bridges nuclear-cytoplasmic transport and RNA regulation. The top hub NUP62 anchors the nuclear pore/transport identity.
Genes
AARS1, APH1A, ARF3, ATG3, CNOT7, CTDNEP1, DCAF7, GNAI2, HCFC1, HNRNPUL2, ISG20L2, KHSRP, LYPLA1, NUCB1, NUP50, NUP62, PLPBP, PPP1CC, PTBP1, RAB11B, RAB14, SCAMP2, SUZ12, SYNCRIP, TNFRSF1A, UBE2Q1, VPS35
Most correlated modules
- Autophagy Vesicular Trafficking · correlation 0.97
- ER Morphology Stress · correlation 0.96
- ER Protein Quality Control · correlation 0.96
- mRNA Splicing Processing · correlation 0.95
- Retromer Endosomal Sorting · correlation 0.95
- Glycogen Metabolism · correlation 0.94
- Actin Cytoskeleton Organization · correlation 0.94
- RNA Processing & Repair · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.