GPR171 — G protein-coupled receptor 171
GPR171 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GPR171's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T cell co-receptors T cell development | AGO4, ARRB2, CAPG, CD200R1, CD40LG, CD96, EMB, FKBP11 +13 more | View in SCUBA |
| Gamma-delta T cells | NK Receptor Expression cytotoxicity | CRACR2B, GFOD1, GPR55, GSTM4, KIR2DL4, KLRC2, KLRC3, MORF4L2 +4 more | |
| Mucosal-associated invariant T cell | T cell Homeostasis T cell maturation | APOL6, CD40LG, CNDP2, FAM118A, FCMR, IFIH1, IL7R, ISG20 +19 more | |
| Natural Killer cells | NK Tissue Residency Gut residency | ENTPD1, GEM, ITGA1, KLHL23, LDLRAD4, PHYKPL, RCAN3 | View in SCUBA |
About the gene
| Synonyms | H963 |
|---|---|
| Chromosome | 3: 151197832-151203216 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
G-protein coupled receptor for Big LEN, a 16-amino acid neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)-alpha-mediated pathway in response to Big LEN. Big LEN-GPR171 system plays an important role in regulating feeding and metabolism. Also plays a role in modulating fear and anxiety-like behaviors in the basolateral amygdala. Big LEN-GPR171 modulates the mu-type opioid receptor signaling and antinociception (By similarity). Acts as a negative regulator T cell function.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.