KDM5B — Lysine demethylase 5B
KDM5B belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KDM5B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | RNA & Chromatin Regulation RNA processing | ATRX, DCP2, DIP2A, HNRNPLL, NCOR1, OGDH, RIOK3, SAMD9 +7 more | View in SCUBA |
| Goblet cells | Nuclear Architecture chromatin regulation & transcription | AK3, AKAP1, ATP1B1, ATRX, DSP, MYO6, NET1, NRIP1 +3 more | View in SCUBA |
| Innate lymphoid cells | NK JAK3 Signaling activation | ANKRD44, APLP2, ATP8B4, CALCOCO2, ERLEC1, FLOT1, FUT8, FYCO1 +10 more | View in SCUBA |
About the gene
| Synonyms | CT31, JARID1B, PLU-1, PPP1R98, RBBP2H1A |
|---|---|
| Chromosome | 1: 202724495-202808487 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transcription factors |
| Molecular function | Chromatin regulator, Dioxygenase, Oxidoreductase, Repressor |
| Biological process | Biological rhythms, Transcription, Transcription regulation |
Function
Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.