Nuclear Architecture
Gene co-expression module in Goblet cells
| Category | chromatin regulation & transcription |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
ATRX is a SWI/SNF-like chromatin remodeling helicase critical for heterochromatin maintenance. KDM5B is a histone H3K4 demethylase. NRIP1 (RIP140) is a nuclear receptor transcriptional co-repressor. SYNE2 (Nesprin-2) and DSP (desmoplakin) contribute to nuclear envelope/cytoskeletal architecture. MYO6 is an actin-based motor. TNRC6B is involved in miRNA-mediated silencing. The dominant program involves chromatin/nuclear architecture and transcriptional repression, with some cytoskeletal components. Suppressed in UC inflammation significantly. Shares neighbor context with M74/M60 chromatin modules.
Genes
AK3, AKAP1, ATP1B1, ATRX, DSP, KDM5B, MYO6, NET1, NRIP1, PRRC2C, SYNE2, TNRC6B
Most correlated modules
- Chromatin Remodeling · correlation 0.82
- mRNA Stability Control · correlation 0.73
- Ion Transport Homeostasis · correlation 0.72
- RNA Decay Processing · correlation 0.70
- Chromatin Remodeling · correlation 0.69
- Adhesion & Transport · correlation 0.68
- Colonocyte Differentiation Program · correlation 0.60
- RNA Splicing · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.