NK JAK3 Signaling
Gene co-expression module in Innate lymphoid cells
| Category | activation |
|---|---|
| Genes | 19 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 19 genes have a known function matching the annotation |
Why this annotation
This module is weakly coherent with low expression and mostly weak membership. Hub genes include ATP8B4 (P4-ATPase lipid flippase), FLOT1 (flotillin-1, lipid raft scaffold), FUT8 (fucosyltransferase 8, core fucosylation of glycoproteins), JAK3 (Janus kinase 3, cytokine signaling in lymphocytes), KDM5B (histone demethylase), RFC1 (replication factor C, DNA replication), APLP2 (amyloid precursor-like protein 2), LIMS1 (LIM domain, focal adhesion), PLSCR1 (phospholipid scramblase 1, interferon-stimulated), CALCOCO2 (NDP52, selective autophagy receptor), FYCO1 (autophagy/lysosome transport), NCAM1 (CD56, NK cell marker), RETREG1 (reticulophagy), LASP1 (actin-binding), HADHB (mitochondrial fatty acid oxidation). NCAM1 (CD56) is a canonical NK cell marker. JAK3 is critical for NK/ILC cytokine signaling. PLSCR1 is interferon-stimulated. The module shows mild inflammation association. The combination of NK identity (NCAM1), JAK3 signaling, and autophagy/membrane remodeling genes suggests an NK cell activation/cytokine-responsive state. Weak coherence limits confidence.
Genes
ANKRD44, APLP2, ATP8B4, CALCOCO2, ERLEC1, FLOT1, FUT8, FYCO1, HADHB, JAK3, KDM5B, LASP1, LIMS1, NCAM1, PLSCR1, RETREG1, RFC1, SNX5, THOC2
Most correlated modules
- RNA Chromatin Regulation · correlation 0.92
- Innate Immune Activation · correlation 0.90
- Antigen Processing MHC-I · correlation 0.90
- Centrosome & Scaffolding · correlation 0.90
- Actin Cytoskeleton Dynamics · correlation 0.90
- ILC Identity Program · correlation 0.89
- TRiC Chaperonin Folding · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.