NET1 — Neuroepithelial cell transforming 1
NET1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NET1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Naive T cell T cell development | AIF1, AK5, APBA2, BEND5, BEX2, C1orf162, CBR3, CYSLTR1 +21 more | View in SCUBA |
| Goblet cells | Nuclear Architecture chromatin regulation & transcription | AK3, AKAP1, ATP1B1, ATRX, DSP, KDM5B, MYO6, NRIP1 +3 more | View in SCUBA |
| Macrophages | Stress Response Transcription Stress | AHR, C11orf96, CBX6, FAM110A, FN3K, GADD45A, LACC1, LPAR6 +8 more | View in SCUBA |
| Pericytes | Smooth Muscle Contractile Cytoskeletal | GPRC5C, MYH11, NRGN, PALLD, PLN, RERGL, SYNE1, SYNM +2 more | View in SCUBA |
| Smooth muscle cells | Wnt-Notch Modulation Development | CLMN, FRZB, HES4, LBH, MAP3K7CL, NRGN, NRIP2, PHLDA2 +1 more | View in SCUBA |
About the gene
| Synonyms | ARHGEF8, NET1A |
|---|---|
| Chromosome | 10: 5412557-5459056 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | Guanine-nucleotide releasing factor |
Function
Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.