KLRC2 — Killer cell lectin like receptor C2
KLRC2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KLRC2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | IEL Gut Residence Gut residence | HOPX, ITGA1, KLRC1, KLRD1, LAT2, SPRY1, TRDC, TRGC1 +1 more | View in SCUBA |
| Gamma-delta T cells | NK Receptor Expression cytotoxicity | CRACR2B, GFOD1, GPR171, GPR55, GSTM4, KIR2DL4, KLRC3, MORF4L2 +4 more |
About the gene
| Synonyms | CD159c, NKG2-C, NKG2C |
|---|---|
| Chromosome | 12: 10426854-10442300 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Receptor |
| Biological process | Adaptive immunity, Immunity, Innate immunity |
Function
Immune activating receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib HLA-E loaded with signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules, likely playing a role in the generation and effector functions of adaptive natural killer (NK) cells and in maternal-fetal tolerance during pregnancy. Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection. Upon HLA-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.