LAT2 — Linker for activation of T cells family member 2
LAT2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LAT2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | MHC-II antigen presentation B cell maturation | CD53, CD81, CYTH1, DAPP1, DNAJC10, FAM3C, FCRLA, GPR18 +11 more | View in SCUBA |
| CD8⁺ T cells | IEL Gut Residence Gut residence | HOPX, ITGA1, KLRC1, KLRC2, KLRD1, SPRY1, TRDC, TRGC1 +1 more | View in SCUBA |
| Gamma-delta T cells | IRF4 T-cell Activation T cell maturation | APOA1, APOA4, CD59, FCER1G, FES, FUCA1, GEM, GRAMD2B +14 more | |
| Macrophages | Retromer Endosomal Sorting Vesicular traficking | ABHD15, ARHGAP45, ARHGAP9, CNPY3, CRBN, CTSO, DAB2, DRAM2 +20 more | View in SCUBA |
| Natural Killer cells | NK Cytotoxic Activation Cytotoxicity | ABI3, ALOX5AP, ARHGDIB, BPGM, CD247, GNPTAB, GZMA, HCLS1 +3 more | View in SCUBA |
About the gene
| Synonyms | HSPC046, LAB, NTAL, WBSCR15, WBSCR5, WSCR5 |
|---|---|
| Chromosome | 7: 74199652-74229834 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Biological process | Adaptive immunity, Immunity, Mast cell degranulation |
Function
Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.